Top-seeded Daniil Medvedev crashed out of the Miami Open Wednesday on a day of upsets that also saw Australian Open champion Naomi Osaka ousted from the quarter-finals.

Top-seeded Daniil Medvedev crashed out of the Miami Open Wednesday on a day of upsets that also saw Australian Open champion Naomi Osaka ousted from the quarter-finals.

Seventh-seeded Spaniard Roberto Bautista Agut beat Medvedev 6-4, 6-2, for his third win in as many meetings with the Russian who was runner-up to Novak Djokovic at the Australian Open and ascended to No. 2 in the world with his victory at Marseille in March.

Women’s world No. 2 Osaka — seeded second behind top-ranked Ashleigh Barty in the prestigious ATP Masters and WTA hardcourt tournament — had bowed out hours earlier.

The Japanese star’s 23-match winning streak coming to a crashing halt with a 6-0, 6-4 loss to Greece’s Maria Sakkari.

Osaka, playing her first tournament since lifting her fourth Grand Slam title at the Australian Open, won just eight points in the first set as she failed to muster a single winner.